MyBioSource.com's MLK4 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot. The MLK4 Antibody was generated using MAP3K21 as the antigen and it reacts with Human.
Description
Description: MLK4 Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Homodimer. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Subunit Structure: Homodimer (By similarity). Interacts with TLR4.
Post-translational Modifications: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily